GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs10935120 | 1 | rs4974483 | chr3:134219001 | ANAPC13 | chr3:134196547-134204865:- | 0.38 | 4.37 | 2.26E-5 | Height |
| UCEC | cis | rs10935120 | 1 | rs4974493 | chr3:134219993 | ANAPC13 | chr3:134196547-134204865:- | 0.4 | 4.63 | 7.74E-6 | Height |
| UCEC | cis | rs60843830 | 1 | rs55753056 | chr2:243929 | SH3YL1 | chr2:218138-264810:- | -0.42 | -5.95 | 1.81E-8 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs10935120 | 1 | rs55913793 | chr3:134285968 | ANAPC13 | chr3:134196547-134204865:- | 0.41 | 4.69 | 6.01E-6 | Height |
| UCEC | cis | rs60843830 | 1 | rs55936726 | chr2:258210 | SH3YL1 | chr2:218138-264810:- | -0.49 | -6.63 | 5.48E-10 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs60843830 | 1 | rs55946380 | chr2:268293 | SH3YL1 | chr2:218138-264810:- | -0.5 | -6.7 | 3.72E-10 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs595244 | 1 | rs55999498 | chr15:48758527 | SHC4 | chr15:49115934-49255641:- | 0.6 | 4.54 | 1.12E-5 | Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) |
| UCEC | cis | rs9309473 | 1 | rs56154726 | chr2:73721767 | ALMS1P | chr2:73872046-73912692:+ | 0.47 | 5.52 | 1.43E-7 | Metabolite levels |
| UCEC | cis | rs60843830 | 1 | rs56167434 | chr2:282137 | SH3YL1 | chr2:218138-264810:- | -0.5 | -6.7 | 3.73E-10 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs595244 | 1 | rs56286136 | chr15:48755814 | SHC4 | chr15:49115934-49255641:- | 0.61 | 4.65 | 7.14E-6 | Intracranial, abdominal aortic or thoracic aortic aneurysm (pleiotropy) |
| UCEC | cis | rs60843830 | 1 | rs56321614 | chr2:268191 | SH3YL1 | chr2:218138-264810:- | -0.43 | -6.01 | 1.35E-8 | Spherical equivalent (joint main effects and education interaction) |
| UCEC | cis | rs9309473 | 1 | rs56672945 | chr2:73622663 | ALMS1P | chr2:73872046-73912692:+ | 0.54 | 6.35 | 2.42E-9 | Metabolite levels |
| UCEC | cis | rs9815354 | 1 | rs56776628 | chr3:41866856 | ULK4 | chr3:41288091-42003660:- | 0.45 | 5.13 | 8.85E-7 | Diastolic blood pressure |
| UCEC | cis | rs568617 | 1 | rs568617 | chr11:65653242 | CTSW | chr11:65647284-65651212:+ | -0.5 | -8.35 | 3.96E-14 | Crohn's disease |
| UCEC | cis | rs9815354 | 1 | rs57479675 | chr3:41798038 | ULK4 | chr3:41288091-42003660:- | 0.52 | 6.19 | 5.36E-9 | Diastolic blood pressure |